Knowledge Base

The Blog

Deep dives into peptides, hormones, nutrition, and everything you need to optimize your health.

Understanding Peptides: What They Are and Why Interest Is Growing

A clear, grounded primer on what peptides are, why they've become mainstream in the wellness conversation, and what to keep in mind before exploring the space.

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Hormones7 min

The Chicken or the Egg: Testosterone vs. GLP-1s

Should you start with hormone replacement therapy or GLP-1s first? Hunter Williams breaks down why the answer might surprise you — and why both paths can work.

Peptides7 min

GHK-Cu Beyond Beauty: New Study Shows Cognitive and Longevity Effects in the Brain

Most people use GHK-Cu for skin and hair. A new preprint from the University of Washington shows intranasal GHK-Cu improves spatial learning in aged mice and suppresses the same pathways as rapamycin and caloric restriction.

Peptides6 min

April 2026 Solo Q&A: 37 Questions on Peptides, Women's Health, GLPs, and More

Hunter answers 37 listener questions covering kisspeptin for women on TRT, optimal estrogen targets, PCOS protocols, GHK-Cu injection tips, PEG-MGF, stacking tirzepatide and retatrutide, MK-677 vs MK-777, and much more.

Peptides8 min

Retatrutide Makes Me Hungrier? A Deep Dive Analysis

Some people get hungrier on retatrutide — not less hungry. Here's the TRIUMPH-4 trial data that explains why, and exactly what to do about it.

Peptides10 min

FDA Peptide Announcement 2025: What It Means for Your Access to BPC-157, TB-500, and More

The FDA just removed BPC-157, TB-500, KPV, MOTS-c, Semax, Epitalon, and six other peptides from Category 2. Here's what actually happened, what comes next, and what it means for how you access peptides.

Peptides7 min

HGH Peptides Cause Cancer?

A critical, evidence-based analysis of a Harvard-led study that looked at tesamorelin's effects on cancer-related gene expression in the liver — and what it means for anyone using or considering GH peptides.

Biohacking8 min

Weirdly-Named Longevity Compound

Spermidine has a strange name, but the research behind it is serious. Hunter Williams breaks down how it triggers autophagy, mimics fasting signals, and what dose actually moves the needle.

Hormones10 min

Hematocrit on TRT Explained

One of the most common things men get scared about on TRT is rising hematocrit. Here's what it actually means, when to worry, and why routine blood donation may be doing more harm than good.

Biohacking8 min

GLP-1s vs. Addiction

A landmark BMJ study of over 600,000 veterans found that GLP-1 drugs reduced substance use disorder risk by 14% across alcohol, nicotine, cocaine, cannabis, and opioids — and cut overdose deaths by 50% in those already addicted.

Biohacking7 min

Spermidine, NAD+, and Longevity: Don't Waste Your NAD+

Spermidine activates autophagy, clears damaged mitochondria, and makes your NAD+ supplementation actually work. Here's the science behind one of longevity medicine's most underrated compounds.

Peptides8 min

Do You Have The GLP Blues? GLP-1 Agonists, Anhedonia, and Emotional Blunting Explained

GLP-1 agonists are transforming metabolic health — but some users report a troubling side effect: emotional numbness and loss of joy. Here's the mechanism behind GLP-1-induced anhedonia and what you can do about it.

Peptides9 min

Retatrutide vs. Cancer: What a New Preclinical Study Reveals About Metabolic Drugs and Tumor Biology

A preclinical study presented at the Society for Immunotherapy of Cancer found that low-dose retatrutide reduced pancreatic tumor growth to a degree comparable to anti-PD1 immunotherapy — without significant weight loss. Here's what that means for longevity.

Biohacking5 min

Brain Repair: Using Peptides to Reverse Concussion Damage

Football gave me a lot, but it took a toll on my gray matter. If you've ever felt that 'static' in your head, you're dealing with chronic neuro-inflammation.

Hormones5 min

The TRT Blueprint: Beyond 'Normal' Hormone Levels

I was 24 years old with the testosterone levels of an 80-year-old man. In 2026, we know that 'Normal' is just a statistical average of an increasingly sick population.

Peptides5 min

BPC-157 & TB-500: The Advanced Recovery Protocol

If you aren't using BPC-157 and TB-500 to address the structural integrity of your tendons, you aren't training—you're just waiting for a tear.

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